Quito - Tena - Baños - Quenca - Vilcabamba - Piura - Arequipa
Boarder CrossingThe trip from Vilcabamba to Piura can be done in a day (leave Vilcabamba at 7am and arrive in Piura at 7pm). There is a direct bus from Loja to Piura. The boarder crossing at Macará is hassle free. I'd rather say it is easy going. The customs officer of the peruvian side was having a siesta when I passed it.
JungleTena is a brilliant place to do jungle trips. It is a bus ride from Quito away and you can do both kinds of jungle trips: the low land Amazon jungle and the cloud forest. I prefer the latter. Virgin jungle is still existing in the inaccessible mountains. You can see enormous trees. What you cannot see are big animals unless they are tame. If you meet any, then it is sheer luck.
MoneyEverything is still cheap in Ecuador and slightly more expensive in Peru. The cheapest hotel room I stayed was 4 USD (Room with private bath including towels and it was clean and quiet)
Do not missIt's huge but it's just another market. Go to lake cuycocha instead...or do both if there is enough time.
TemperatureDon't be paranoid. Arequipa has a bad reputation. I felt like being in Davos.